Monthly mean atmospheric CO2 in PPM at Mauna Loa, Hawaii (source: NOAA/ESRL).
If you tell Flot that an axis represents time, the data will be interpreted as timestamps and the ticks adjusted and formatted accordingly.
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The timestamps must be specified as Javascript timestamps, as milliseconds since January 1, 1970 00:00. This is like Unix timestamps, but in milliseconds instead of seconds (remember to multiply with 1000!).